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Hyperfixed

Hyperfixed & Radiotopia

Maybe it’s just a quiet annoyance you’ve grudgingly learned to put up with, or a life defining issue that makes it hard to move forward. Whatever it is, Alex Goldman — reporter, radio producer, and overconfident idiot — will get to the bottom of it (if there’s a bottom to be found. Results may vary). Follow Alex as he figures out not only the vast hidden mechanisms that create these problems, but works with you, the listener, to find a solution. Or at least enough of an explanation that you’re ok with the annoyance. He’s not perfect. Hyperfixed is a proud member of Radiotopia from PRX, a network of independent and listener-supported podcasts. Discover audio with vision at radiotopia.fm. 

Submit your problems and sign up for bonus episodes and much more at hyperfixedpod.com

© Copyright 2024 Hyperfixed

Maybe it’s just a quiet annoyance you’ve grudgingly learned to put up with, or a life defining issue that makes it hard to move forward. Whatever it is, Alex Goldman — reporter, radio producer, and overconfident idiot — will get to the bottom of it (if there’s a bottom to be found. Results may vary). Follow Alex as he figures out not only the vast hidden mechanisms that create these problems, but works with you, the listener, to find a solution. Or at least enough of an explanation that you’re ok with the annoyance. He’s not perfect. Hyperfixed is a proud member of Radiotopia from PRX, a network of independent and listener-supported podcasts. Discover audio with vision at radiotopia.fm. 

Submit your problems and sign up for bonus episodes and much more at hyperfixedpod.com

© Copyright 2024 Hyperfixed
14hr 32min
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The Cat Drug Black Market

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July 17, 202543min 25sec

When Marlena's cat was diagnosed with a terminal disease, she found herself seeking help not from a vet, but a series of websites and Facebook groups. The first in a three-part series.

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LINKS:

GS treatment available in pharmacies: https://bestfriends.org/sites/default/files/2024-11/Network_09%20Webinar_FIP%20Treatment_US-Pharmacy-FIP-Treatment-Options.pdf

Dr. Pedersen's 2019 paper

FIP Warriors Facebook Group

Gilead's statement: 

Since Gilead identified GS-441524 as a potential treatment for cats with feline infectious peritonitis (FIP), we made it available to institutions with the expertise to advance medicines for veterinary use. This is why we shared GS-441524 with UC Davis to research its impact on FIP.

GS-441524 is an intermediate in the synthesis of remdesivir, an approved treatment for COVID-19. Gilead’s supply of GS-441524 was and continues to be used to manufacture remdesivir to meet the demands of COVID-19.

Today, remdesivir has been made available to more than 14.5 million patients around the world, including more than 8.1 million in low- and lower-middle income countries.

In parallel, Gilead has made progress in studies identifying prodrugs of GS-441524 with improved oral bioavailability that could be further investigated as a therapeutic for FIP in cats. Discussions with suitable veterinary specialty companies are ongoing, but to-date we have not identified an appropriate partner. Gilead supports finding a solution for FIP at the earliest opportunity.

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The Cat Drug Black Market
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